What is the difference between Ozempic and Wegovy?

Both contain semaglutide, manufactured by Novo Nordisk. Ozempic is FDA-approved for type 2 diabetes at doses up to 2mg weekly. Wegovy is FDA-approved for chronic weight management and cardiovascular risk reduction at doses up to 2.4mg weekly. The molecule is identical — the differences are regulatory indication, maximum dose, and insurance coverage. Wegovy also has a cardiovascular risk reduction claim based on the SELECT trial that Ozempic does not carry.

How much weight will I lose on semaglutide?

In the STEP 1 trial, average weight loss with semaglutide 2.4mg was 14.9% of body weight over 68 weeks (approximately 33 pounds for a 220-pound starting weight). Individual results vary widely — about one-third of participants lost 20% or more, while some lost less than 5%. Factors influencing response include genetics, baseline metabolic status, adherence to the titration schedule, diet, and exercise habits.

Is compounded semaglutide safe?

Compounded semaglutide quality varies significantly between vendors. TriedRx testing of 920 samples from 84 vendors shows purity ranging from below 90% to above 99%, with meaningful differences in potency and sterility. Compounded semaglutide from a reputable pharmacy using third-party tested, high-purity peptide can be a viable option. However, there is no FDA oversight of the final compounded product's quality — which is why independent testing data like TriedRx provides is valuable for making informed decisions.

How long do I have to take semaglutide?

Current evidence suggests that semaglutide must be taken indefinitely to maintain weight loss. The STEP 4 trial showed that participants who stopped semaglutide after 20 weeks regained most of their lost weight within a year. This is consistent with the understanding that obesity is a chronic condition driven by hormonal and neurobiological factors — semaglutide corrects these factors while it is being taken, but does not cure the underlying condition.

Can I take oral semaglutide instead of injections?

Yes. Rybelsus (oral semaglutide) is FDA-approved for type 2 diabetes. However, oral semaglutide has lower bioavailability than injectable semaglutide, and the maximum approved oral dose (14mg daily) produces less weight loss than the injectable weight-management dose (2.4mg weekly). It also has strict dosing requirements — empty stomach, minimal water, 30-minute wait before eating. For dedicated weight management, injectable semaglutide (Wegovy) is generally more effective.

What happens if I miss a dose of semaglutide?

If you miss a dose and the next scheduled dose is more than 2 days away, take the missed dose as soon as possible. If the next dose is 2 days or less away, skip the missed dose and take the next dose on schedule. Do not double up. Semaglutide's 7-day half-life provides some buffer against missed doses, but consistent weekly dosing produces the best results.

Does semaglutide cause hair loss?

Hair loss (alopecia) has been reported by some patients on semaglutide, though it was not a statistically significant adverse event in pivotal trials. The hair loss is most likely telogen effluvium — a temporary shedding triggered by the physiological stress of rapid weight loss and caloric deficit, rather than a direct drug effect. It typically resolves over several months as weight stabilizes, particularly when nutritional intake (protein, iron, zinc, biotin) is adequate.

Vendor Rankings

Independent rankings of peptide vendors based on aggregated lab data, COA transparency, community sentiment, and verified pricing. We publish everything — including the failures.

317+ samples tracked 107 vendors ranked 15 peptides tracked

All BPC-157 Tirzepatide Semaglutide CJC-1295 Ipamorelin GHK-Cu Retatrutide Tesamorelin

AGreat

B+Very Good

BGood

COkay

DPoor

EBad

FFraud

Semaglutide Rankings

FDA-APPROVED

317 samples across 107 vendors · Updated weekly from independent lab testing

#	Vendor	Avg score	Purity range	Tests	Verified $/mg	Grade	Profile
Grade B+ — Very Good
1	Bulk Peptide Supply	8.3	—	5	—	B+	review →
2	Royal Peptides	8.1	—	8	—	B+	review →
3	Shanghai Sigma Audley SSA	8.0	—	10	—	B+	review →
4	Peptide-S	7.8	—	6	—	B+	review →
5	Peptide Gurus	7.7	—	6	—	B+	review →
6	PeptiSlim	7.6	—	4	—	B+	review →
Grade B — Good
7	Bulk Peptide Wholesale	7.5	—	3	—	B	review →
8	Uther	7.5	—	3	—	B	review →
9	Planet Peptide	7.4	—	8	—	B	review →
10	Wuhan Wansheng Biotechnology	7.3	—	5	—	B	review →
11	Yiwu Aozuo Trading Co	7.3	—	2	—	B	review →
12	ZLZ Peptide	7.2	—	11	—	B	review →
13	SRY Labs	7.2	—	4	—	B	review →
14	HK Peptides	7.1	—	10	—	B	review →
15	Xian Yihang Technology	7.0	—	4	—	B	review →
16	Zhejiang Yichenkang Biotechnology	7.0	—	7	—	B	review →
17	Shenzhen Loga Tech LG LOGA	7.0	—	4	—	B	review →
18	Oupeptide	6.7	—	6	—	B	review →
19	Peptide Crafters	6.7	—	10	—	B	review →
20	TSC Top Supplements China	6.7	—	4	—	B	review →
21	Risynth Bio	6.6	—	4	—	B	review →
22	Polaris Peptides	6.6	—	17	—	B	review →
23	Skye Peptides	6.6	—	9	—	B	review →
24	Paramount Peptides	6.6	—	9	—	B	review →
Grade C — Okay
25	Amplified Amino	6.4	—	4	—	C	review →
26	Bfflist AMO	6.3	—	3	—	C	review →
27	Tydes	6.2	—	9	—	C	review →
28	Simple Peptide	6.2	—	4	—	C	review →
29	Injectify	6.0	—	4	—	C	review →
30	Tianjin Ruiwang New Material Technology Co	6.0	—	5	—	C	review →
31	Atomik Labz	6.0	—	4	—	C	review →
32	Amino Amigos	6.0	—	7	—	C	review →
33	Verified Peptides	6.0	—	4	—	C	review →
34	Peptide Technologies	6.0	—	4	—	C	review →
35	Accelerate Labs	5.9	—	3	—	C	review →
36	Liberty Peptides	5.8	—	5	—	C	review →
37	Amino Asylum	5.7	—	2	—	C	review →
38	Forever Young Pharmacy	5.7	—	5	—	C	review →
39	NextechLabs	5.7	—	2	—	C	review →
40	Deuschem	5.6	—	4	—	C	review →
41	Astro Peptides	5.6	—	7	—	C	review →
42	Elite Research USA	5.4	—	9	—	C	review →
43	Suaway Lab Research	5.3	—	5	—	C	review →
44	Alpha-Gen	5.3	—	5	—	C	review →
45	Pure Rawz	5.2	—	4	—	C	review →
Grade D — Poor
46	Nuscience Peptides	5.0	—	14	—	D	review →
47	Precision Peptide Co	5.0	—	4	—	D	review →
48	Pharma Grade Peptides	5.0	—	2	—	D	review →
49	Platinum Cryo	4.6	—	6	—	D	review →
50	Nexaph	4.5	—	15	—	D	review →

Verified $/mg = list price ÷ (avg tested qty / labeled qty). Vendors below the cutoff omitted from view.